EVALUATION OF PROGRAM DEATH 1 (PD-1) AND PD-1 LIGAND (PD-L1) EXPRESSIONS IN HISTOLOGICAL SUBTYPES OF PRIMARY EXTRANODAL NON HODGKIN LYMPHOMA.
نویسندگان
چکیده
Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid tumours. However, only limited observations were made lymphomas, which mainly Hodgkin lymphomas. We aimed to evaluate the expressions of PD-1 tumour microenvironment cells primary extranodal non-Hodgkin lymphoma (peNHL). A cross-sectional study using 87 archived formalin-fixed paraffin-embedded tissue blocks from patients diagnosed with peNHL. Immunohistochemistry stainings for done. The evaluated microscopically. association between histological subtypes peNHL statistically analysed. 46 (52.9%) cases had a negative expression 57 (65.5%) positive microenvironment. Significant associations found (p<0.05). Positive both diffuse large B cell (DLBCL). Our explored has demonstrated significant peNHL, may provide additional information future these proteins.
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ژورنال
عنوان ژورنال: Malaysian applied biology
سال: 2021
ISSN: ['0126-8643', '2462-151X']
DOI: https://doi.org/10.55230/mabjournal.v50i2.1987